Best weight loss peptides for men, ranked on the decision that comes with them
Carrying extra weight suppresses testosterone, and losing it brings the number back. So a man starting a GLP-1 usually ends up facing a second question — and the obvious answer to that one suppresses sperm production, which the label says and nobody selling it quotes you. Only 3 of these 16 providers can handle both sides of it.
Testosterone works faster, and costs your sperm count
Depo-Testosterone's Precautions: “Oligospermia may occur after prolonged administration or excessive dosage.” Its Clinical Pharmacology section explains the mechanism — exogenous androgen suppresses pituitary LH and, at larger doses, FSH. In the classic trials 65% of 271 men on a weekly injection reached azoospermia, at a mean of 120 days. It reverses: across 1,549 men in 30 studies the median return to 20 million per millilitre was 3.4 months, 67% recovered by six months and 90% by twelve — slower with longer treatment and longer-acting esters.
The GLP-1 works slower, and leaves the plumbing alone
In the one randomised head-to-head — 25 men with type 2 diabetes and functional hypogonadism, semaglutide against testosterone undecanoate over 24 weeks — morphologically normal sperm rose from 2% to 4% on semaglutide while sperm concentration and total count fell in the testosterone arm. Both raised total testosterone. Erectile function improved only on testosterone. A ten-study review found LH and FSH preserved or increased on GLP-1s, against suppression in the testosterone comparators. Twenty-five men and one open-label trial — small, and a direct comparison of exactly these two choices.
Label text read from the current prescribing information on DailyMed on 2026-07-31; trials pulled from PubMed the same day. None of it applies to a compounded product, which carries no FDA label — every GLP-1 on this board is compounded.
/ The board
Some of these are affiliate links and we may earn a commission at no extra cost to you (disclosure). Rows marked Partner are the paid ones. Full write-ups below.
“Flat price” means one all-in monthly figure with no separate membership or lab fee; any other pricing chip names the mechanic that gets in the way. “Labs” is whether bloodwork is required, optional, or not used. The pharmacy chip states a facility type (503A pharmacy, 503B facility) only where the provider publishes one we could cite; “Not disclosed” means we read their site and they do not say, and “Unverified” means nobody has checked this company's pharmacy sourcing yet — of the providers we rank, only two publish a facility type at all. Every provider here includes the clinician consult. Prices were verified on each provider's own site in 2026 and can change without notice.
Both sides of the fork, one account
$209–$149/mo (prepay, inconsistent)
1
HealthRX
The only provider here selling a GLP-1, real testosterone and enclomiphene — and no lab panel at all.
Two different headline figures appear on two different pages of the same site: healthrx.com (homepage) advertises "from $209/mo" (a 3-month plan) while healthrx.com/tirzepatide (the dedicated product page) advertises "from $149/mo" (described as an annual plan). Neither is a plain 1-month rate.
The one row where every arm of the androgen fork is purchasable from one account: compounded tirzepatide and semaglutide, testosterone cypionate at a stated 200 mg/mL in a 5 mL vial, and enclomiphene, which nudges your own production instead of replacing it and does not carry testosterone's effect on sperm output. That combination is genuinely rare on this roster. What is missing is the thing that should drive the choice between them. Its testosterone product's own strapline is that it is prescribed on your labs, and no lab panel is sold, priced or offered anywhere in the flow — so the decision with a fertility cost attached to it is the one you are expected to make without bloodwork.
Strengths
GLP-1, testosterone and enclomiphene all available from one provider, so the androgen fork does not require a second account
Enclomiphene specifically is the option that raises testosterone without the labelled suppression of sperm production that replacement carries
Its testosterone line publishes both a subscription and a genuine one-time price, and states the concentration and vial size
Trade-offs
Sells no lab panel at any price, while advertising treatment prescribed on your labs — the fork this page is about is a lab decision
Its GLP-1 pricing is internally inconsistent on both molecules, so the drug you would actually start on is the one whose cost is least clear
No haematocrit-monitoring cadence is published, which is the standard safety concern on long-term testosterone
Visit HealthRX ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
The rest of the field
15 more providers, ordered from those that can run both sides of this decision down to those that will not name the molecule they ship. Every price is inherited unchanged from the rendered-browser check behind our tirzepatide board — this page re-argues the field, it does not re-price it.
2
Try Ageless
GLP-1 and testosterone in three formats at one price, and a blood test it promises and does not sell.
Tirzepatide Injection: list $219, sale $169 (23% off). Tirzepatide Drop (oral): list $299, sale $249 (17% off). Neither product page states what unlocks the sale price — no promo code, auto-refill, or prepay term is named on the storefront grid.
Compounded telehealth carrying both GLP-1 molecules alongside a testosterone line in injection, topical and oral tablet at a single figure, so format is a clinical choice rather than a budget one. On this board's lens that puts it second: the androgen side is real, purchasable and priced. Two things hold it there. Its testosterone copy promises treatment guided by comprehensive biomarker blood testing, and no blood test is sold, priced or scheduled anywhere on the site. And every price on every product page carries the brand's standing footnote making the final amount dose-dependent after clinical review.
Strengths
A real testosterone line at a published rate, in three delivery formats priced identically
Both GLP-1 molecules on the same account, so a switch between them does not mean a new provider
Also carries sermorelin and NAD+ if the rest of the stack matters to you
Trade-offs
Promises treatment guided by comprehensive blood testing while selling and scheduling no blood test
Every price is disclaimed as dose-dependent, so neither the GLP-1 nor the testosterone figure is a rate you can budget against
No strength, vial size or concentration published for any testosterone format, so the price attaches to no stated quantity
Visit Try Ageless ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
3
Strut Health
The fertility-sparing androgen option — and it is deliberately not testosterone.
$239/month standard 30-day supply, or $199/month with auto-refill enrollment (a 17% discount)
Markets a category called Testosterone and sells no testosterone in it. The product behind it is enclomiphene, with or without tadalafil, at a stated 30-day price on auto-refill. On most of this site that is a category error worth calling out, and we do call it out on our testosterone board. On this page it is close to the point: enclomiphene raises your own production through the pituitary rather than replacing the hormone, so it does not carry the labelled suppression of sperm output that replacement does. For a man who wants the androgen side addressed and wants to keep his fertility intact, that is the correct product and this is the only row selling it alongside a GLP-1 at a published price.
Strengths
Enclomiphene at a published 30-day price, beside both GLP-1 molecules, from one provider
The one androgen option here with no labelled effect on sperm production — the specific trade-off this page exists to explain
Segments its weight-loss catalogue by sex on its own site rather than selling one undifferentiated programme
Trade-offs
Sells no actual testosterone, so if replacement is what you need this is not the provider — and its own category name says otherwise
Both the enclomiphene and the headline GLP-1 rates require enrolling in auto-refill
Received an FDA warning letter (2026-02-20) over marketing claims
Visit Strut Health ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
4
yourEra
The cheapest clean tirzepatide rate on the board, from a provider with no androgen side at all.
$169/month, no long-term contract — the site states you can pause or cancel any time
Compounded GLP-1 telehealth publishing a specific tirzepatide figure with a stated same-price-at-every-dose policy — so titrating up toward the doses where the body-composition data was generated does not reprice the plan. On the molecule half of this page's lens it does well. On the androgen half it does nothing: there is no testosterone, no enclomiphene and no hormone panel here, so a man who turns out to have low testosterone leaves this provider to find out and leaves it again to do anything about it.
Strengths
A specific tirzepatide rate rather than a band, with a stated flat price at every dose
The molecule the pooled lean-mass data favours is the one priced most clearly here
Telehealth visit, prescription and shipping described as included
Trade-offs
No testosterone, no enclomiphene and no hormone panel — the androgen fork cannot be managed here at all
This site was found publishing a separate product whose own purchase links returned 404, so a reachable advertised price is not a given
Thin independent footprint; coverage and outcome claims are self-reported
Visit yourEra ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
Full write-ups for the remaining 12 providers▾
5
Bodybuilding Health+
Both molecules priced cleanly, in the catalogue built for lifters, with no hormone line behind it.
BH
$209/month with no prepay required, billed monthly; discounted tiers exist for 3-, 6-, and 12-month prepay ($179 / $169 / $159/mo)
The compounded-Rx arm of retailer Bodybuilding.com, and the roster's most obvious fit for this page's audience: alongside both GLP-1 molecules it carries the recovery and GH-peptide catalogue a training population actually asks about. Tirzepatide is named and priced at a clean figure. What the catalogue does not contain is a hormone line — no testosterone, no enclomiphene — so the fork this board ranks on has to be handled somewhere else, and everything here sits on prepay plan lengths that penalise changing your mind.
Strengths
Both molecules named and separately priced, at the lowest clean pair of figures on this board
Deep recovery and GH-peptide catalogue beside the GLP-1s, which is the stack this audience asks about
A genuine 1-month plan length is described as available
Trade-offs
No testosterone or enclomiphene line, so the androgen half of the decision is not served here
Both figures sit on prepay plan lengths, and all sales are final with a non-refundable consult
A brand-new operator licensing an older retailer's name — the heritage is the shop's, not the telehealth's
Both molecules, the full tier ladder printed — and a billing cycle worth reading twice.
$329/month with no prepay required; drops to $313/$296/$280 per month on 3-/6-/12-month prepay tiers, and a promo code takes $50 off the first order only
Compounded GLP-1 telehealth that prints its whole plan ladder with the saving against each tier, which is more disclosure than most of this board manages. Tirzepatide is named and priced. The detail to check before prepaying: on this company's longevity line every tier bills on a four-week cycle while quoting a monthly price, which is thirteen charges a year rather than twelve. Confirm whether the weight-loss plan you are quoted does the same, because on a twelve-month tier that difference is roughly an extra month of medication.
Strengths
Both molecules named and priced, with the complete tier ladder and the discount against each on one page
A genuine shortest-term option exists rather than a mandatory quarterly prepay
Provider care described as included in the plan price
Trade-offs
No testosterone or enclomiphene line — the androgen fork is not served
Its other product lines bill on a four-week cycle while quoting a monthly rate; confirm the cadence before prepaying
The advertised floor is only reachable on the longest commitment
Visit Enhance MD ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
7
Direct Meds
Both molecules at a rate with no lever attached, and the highest figures here.
$399/month, stated on-site as billed every month, with no prepay or auto-refill lever found
Compounded GLP-1 telehealth naming both molecules and pricing each on its own, with neither figure resting on a prepay tier, an auto-refill enrolment or an introductory month. If you intend to start on tirzepatide for the body-composition reason this page sets out and want to know what month two costs before you begin, this is the cleanest answer on the board — and the most expensive. There is no hormone line, so the androgen side goes elsewhere.
Strengths
Both molecules separately named and priced, with no commitment lever behind either figure
A molecule switch does not reprice or forfeit anything, because nothing was prepaid
The published figure is the ongoing figure — rarer here than it should be
Trade-offs
The highest published price on this board for either molecule
No testosterone, enclomiphene or hormone panel
Thin wrapper — no bundled coaching or dietitian support at a price above every competitor
Visit Direct Meds ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
8
MadeMed
Real clinical process, both molecules, and no month-to-month plan at any price.
$399/month on a 3-month prepay (the shortest commitment offered), or $369/month on a 6-month prepay
Compounded telehealth running more pre-prescribing process than most of this field, including required bloodwork on some lines — which on a page about a decision that should be driven by labs is a genuine point in its favour. The structural problem is the term. The shortest commitment on any product line here is a quarterly prepay, so if a hormone panel comes back and changes what you should be taking, it changes it against a quarter you have already bought.
Strengths
Requires bloodwork before prescribing on some lines, which is real clinical caution rather than a checkout
Both molecules named and priced, with the most specific dosing disclosure on our NAD+ board from the same company
Consultation, supplies and shipping stated as included
Trade-offs
No month-to-month option at any price — the shortest term is a quarterly prepay
The required lab work is not priced anywhere, so the real cost of starting is unknowable from the page
Visit MadeMed ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
9
Sprout Health
Both molecules named, both figures missing the mechanism that produces them.
"Starting at $349" shown struck through, marked down to "now from $199" — the site does not explain what unlocks the lower figure
Compounded GLP-1 weight-loss telehealth. Both drugs are named, so the molecule choice is at least available, but neither figure states what produces it — the semaglutide number describes a multi-month supply and the tirzepatide number's mechanism is not published at all. Also worth weighing: this company received an FDA warning letter in September 2025 over marketing its compounded GLP-1s as FDA-approved, which is exactly the confusion a reader has to see through before any of the labelled findings on this page can be applied to a compounded product.
Strengths
Both molecules named as distinct products
Unusually direct elsewhere on the site that compounded products are not FDA-approved or FDA-evaluated
States plainly that it is not the pharmacy and not the manufacturer
Trade-offs
Neither published figure states its pricing mechanism
Received an FDA warning letter (2025-09-09) over marketing compounded GLP-1s as FDA-approved
Visit Sprout Health ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
10
Oak Longevity
Tirzepatide named and priced — beneath a no-subscription banner and three unreconciled figures.
Tirzepatide is advertised "from $185/mo". For semaglutide the same site shows $119 in the homepage hero, $167 in its own comparison table further down that page, and $190 on the weight-loss page — with a "$200 off new patient" banner running above the lowest figures and no stated relationship to them
Compounded GLP-1 telehealth naming both molecules on a public site rather than behind a quiz, which is worth something. The rendered-browser check found three different semaglutide prices across three of its own pages, sitting under a banner promising one price with no subscriptions. The molecule is specifiable; what it costs is not a number this site states once.
Strengths
Both molecules named, so the drug you receive is specifiable
Prices published on the public site rather than gated behind an intake quiz
Advertises a one-price, no-subscription model rather than a tier ladder
Trade-offs
Three unreconciled semaglutide prices found across the site's own pages
The promotional mechanics behind the banner figures are quiz-gated and cannot be checked
Visit Oak Longevity ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
11
RxSpan MD
A tirzepatide price labelled first-month-only, from a site with no hormone category at all.
Tirzepatide Injection $329, Tirzepatide Capsules $349 — both explicitly "for the first month"; no ongoing/renewal price is shown anywhere on the site or in the checkout flow
Physician-led telehealth with a broad menu — weight loss, sexual health, hair regrowth, longevity — and no hormone-therapy category anywhere on it, which is worth stating because a payout tier and a category name have both made this company look like a testosterone seller before. On the molecule half of the lens the tirzepatide figure carries the brand's site-wide first-month-only label while a cancel-anytime monthly tier is sold at the same number; both statements cannot be true.
Strengths
Both molecules named as separate products with separate figures
Inclusions stated explicitly — consult, medication, supplies, shipping and support
Available in all 50 states, stated plainly
Trade-offs
The tirzepatide price is labelled first-month-only while the plan selector sells a monthly tier at the same figure
No hormone-therapy category exists on the site, despite appearances elsewhere
No product detail is reachable outside the intake quiz
Visit RxSpan MD ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
12
Synergy Rx
Tirzepatide named as a real product, with no terms published behind it.
"Starting at $349" for Compounded Tirzepatide (injectable), or "Starting at $399" for an oral dissolving tablet — no dose basis, billing term, or commitment is stated on the product card
Compounded GLP-1 and longevity telehealth whose storefront names tirzepatide as a real, priced product — which clears the molecule bar — and then publishes nothing behind the card. Clicking through goes to the intake quiz, not a product page, so dose basis, billing cadence and consult inclusion are all unavailable before you register. Its longevity tab does carry sermorelin and NAD+, but no testosterone.
Strengths
Both molecules named as real, separately priced products, confirmed in a rendered browser
A sermorelin and NAD+ line on the same storefront if the wider stack matters
Free shipping stated site-wide
Trade-offs
Neither figure carries terms — no dose basis, no cadence, no confirmation it is a no-lever rate
The route from price to product is the intake quiz
A site-wide promo banner names no discount amount, so the displayed price cannot be checked against anything
Visit Synergy Rx ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
13
SHED
Its semaglutide listing is a generic GLP-1 SKU — so the lean-mass question has no answer here.
$299/month with no prepay required; drops to $269/mo on a 6-month prepay or $239/mo on a 12-month prepay
Tirzepatide itself is named and priced. The problem is the other half of the shelf: the semaglutide-shaped product a shopper can actually buy is a generic GLP-1 Injections SKU whose own copy does not guarantee which molecule ships, and the same weight-loss menu carries orforglipron as well. On a page whose molecule argument is a published 25.4%-versus-35.2% difference in how much of the weight lost is lean tissue, a product that will not name its molecule cannot be assessed on it at all.
Strengths
A genuine brand-name Zepbound path is offered for readers who want the approved product and its actual label
Health coaching bundled into the membership rather than sold on top
The tirzepatide product itself is named and separately priced
Trade-offs
The semaglutide-shaped product is a generic GLP-1 SKU whose own copy does not name the molecule dispensed
So the body-composition comparison this page turns on cannot be applied to half of what is on sale
A site-wide banner advertises a price the product page does not match, and the dispensing pharmacy is not named
Visit SHED ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
14
Gala Health
A women's hormone practice that sells a blended GLP-1 SKU and no testosterone at all.
$179/month on a 12-month prepay, or $199/month on a 3-month prepay; no 1-month rate published
Ranked last on the lens for two independent reasons, and the honest thing is to say what it is instead of burying it. Gala is a women's hormone-therapy practice — estradiol and progesterone — which makes it the most interesting provider on our roster for the perimenopausal reader on our women's page, and one of the least relevant here: there is no testosterone product anywhere on the site. Its GLP-1 figures describe a blended GLP-1/GIP product rather than a tirzepatide-dedicated one, so the molecule cannot be pinned down either.
Strengths
Consult and ongoing support described as bundled into the price
The longest prepay tier is among the lowest advertised GLP-1 figures on this board
Genuinely strong at what it does do — see our women's weight-loss board, where its hormone practice is the point
Trade-offs
No testosterone product exists anywhere on the site, so neither arm of the androgen fork is served
The published figures describe a blended GLP-1/GIP SKU, not a tirzepatide-dedicated one
No month-to-month option published; both figures require multi-month prepayment
Visit Gala Health ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
15
Breeze Meds
Tirzepatide named in the navigation, priced nowhere.
Pricing not published — every product link leads straight into an intake quiz with no price shown at any step
Compounded GLP-1 and longevity telehealth. Tirzepatide and oral tirzepatide are named products in the site's own navigation, and no figure is published for either — every route to a price runs through the intake quiz. Its longevity line does now publish prices, so the weight-loss blackout is a choice rather than an unfinished site. No hormone line.
Strengths
Both molecules named as real products in the site's own catalogue
Now publishes prices on its longevity line, so the capability plainly exists
Named injection frequencies elsewhere are more detail than several priced competitors give
Trade-offs
No price is published for either molecule; every route to one is the intake quiz
No testosterone or enclomiphene line
The site's own navigation redirects off-domain to sibling white-label telehealth sites
Visit Breeze Meds ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
16
Care Bare Rx
Both molecules named, one category-wide floor, nothing priced to either drug.
Pricing not published — a $199/mo figure exists only as a category-wide "starting at" floor across all weight-loss drugs, not tied to tirzepatide specifically
White-label telehealth naming both molecules with no figure specific to either — only a category-wide weight-loss floor, which cannot price the molecule choice this page turns on. It does carry a sexual-health line, but no testosterone product and no hormone panel, so the androgen fork is not served here either.
Strengths
Both molecules named rather than sold as an unnamed weight-loss programme
Broad catalogue if you want one provider for several things
The category floor is at least stated publicly rather than hidden entirely
Trade-offs
No price specific to either molecule is published anywhere
A category-wide floor cannot price a molecule choice
No testosterone and no hormone panel, despite a sexual-health category that might suggest otherwise
Visit Care Bare Rx ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
Straight talk: how we earn — some, not all, of these are affiliate links; start a program through one and we may earn a commission at no extra cost to you. Straight about the rest, too: the write-ups say what each provider is actually worth, and a commission does not change a word of them. Full disclosure here.
How we rank
We do not run sponsored reviews, and nobody pays us to change what we write about a provider. Affiliate partners are listed ahead of non-partners, and the ordering within that group runs on the four factors below — deliberately different from every sibling board, because the question here is not what the drug costs. It is what starting the other one costs.
Can one provider run both sides of the fork
Obesity suppresses testosterone and weight loss brings it back, so a man starting a GLP-1 with a low number has a real choice — and the two arms differ on fertility, which makes it a lab decision rather than a preference. Only 3 of the 16 providers here sell a GLP-1 alongside an androgen line at all. The other 13 mean a second account, a second clinician and nobody holding both sets of results.
Which molecule, for body composition
Second: lean tissue was 25.4% of the weight lost on tirzepatide against 35.2% on semaglutide, pooled across 20 randomised trials. That is a genuine molecule-level difference on the outcome this site's audience cares about, so a provider that names and prices tirzepatide separately ranks above one that sells an unnamed GLP-1.
Whether the bloodwork the decision needs is sold at all
Third, and it is where the top of this board loses points rather than gains them: the two providers with the best androgen catalogues both advertise treatment guided by bloodwork and sell no blood panel at any price. We rank them first because the products exist, and say plainly that the test driving the choice between them does not.
What we refused to rank on
Not muscle preservation as a drug property. The same pooled dataset puts lifestyle-only weight loss at 26.2% lean — statistically no different from the incretins — and resistance training at 17.5%. So no row here is penalised as though these drugs were uniquely catabolic, and no row is credited with a muscle-sparing claim nobody has evidence for. See our full evidence page for men.
The muscle question, with the number that actually moves it
Pooled across 20 randomised trials and 15,782 people measured by DXA or MRI, lean tissue was 25.4% of the weight lost on tirzepatide, 26.8% on liraglutide and 35.2% on semaglutide. That molecule gap is real, and it is why this board rewards providers that name and price tirzepatide separately rather than selling an unspecified GLP-1.
What the same dataset does not support is the line everyone repeats. Lifestyle-only weight loss ran 26.2% — statistically indistinguishable from the incretins as a group. Losing weight costs lean tissue whatever causes it. The only intervention in that analysis that changed the number was resistance training, at 17.5%, which is both the least commercial sentence on this page and the most useful one. If you are on this site you probably already lift; keep lifting, and eat enough protein to make it count.
One honest limit on the sex angle: the only sex-stratified body-composition result comes from a post-hoc analysis of the tirzepatide substudy — 75% fat and 25% lean in women, 73% and 27% in men, with no significant difference detected. There were about 43 men in it. That is an underpowered null, which means no difference was found, not that none exists, and no equivalent result has been published for semaglutide at all.
If you are drug-tested, testosterone is banned year-round — and a prescription is not a defence
That is a harder line than anything on our peptide boards, and it does not soften with a valid prescription unless an exemption was granted before you started. Check any compound in the banned-in-sport checker. The GLP-1s are a different question entirely — see the checker for each.
★ What changed in the labels, and what did not. The cardiovascular boxed warnings were removed from Xyosted and Jatenzo in March 2025 after the TRAVERSE outcomes trial, which found major adverse cardiac events in 7.0% on testosterone gel against 7.3% on placebo. Depo-Testosterone never carried one. The only testosterone boxed warning we found still in force is on topical gels, about virilisation in children secondarily exposed to an unwashed application site. What went less reported is in the same label's adverse-reaction table: bone fracture 3.5% against 2.5%, non-fatal arrhythmias warranting intervention 5.2% against 3.3%, acute kidney injury 2.3% against 1.5%. Different testosterone products currently say different things about cardiovascular risk — read the one you were prescribed, not “the testosterone label”.
This board ranks on whether one provider can run both sides of the androgen decision. If you have already made it and want the hormone side priced properly, that is our online TRT ranking, where the medication turns out to be the smallest line on the bill. For the drug price alone, our tirzepatide and semaglutide boards ask narrower questions. And the women's version of this board prefers the opposite molecule, for a reason that has nothing to do with body composition.
Questions we get asked
Does testosterone therapy affect fertility?▾
Yes, and it is on the label. Depo-Testosterone's Precautions section states that oligospermia may occur after prolonged administration or excessive dosage, and its Clinical Pharmacology section explains why: exogenous androgen suppresses pituitary LH and, at larger doses, FSH, which is what drives sperm production. Xyosted's section 5.7 says the same in modern label language and instructs that patients be informed of the risk when deciding whether to start. In the classic contraception trials, 65% of 271 healthy men on a weekly injection reached azoospermia, at a mean of 120 days. It reverses: pooled across 1,549 men in 30 studies, the median return to 20 million sperm per millilitre was 3.4 months, with 67% recovered by six months and 90% by twelve. Recovery was slower with longer treatment and with longer-acting esters, and those trials used healthy men on supraphysiologic doses — they are a guide, not a guarantee for someone six years into therapy.
Does losing weight on a GLP-1 raise testosterone?▾
The evidence says yes, modestly, and it is thinner than the confidence around it. A meta-analysis of 24 studies found endogenous testosterone rose after weight loss, most after bariatric surgery and less after dieting, with the degree of weight loss the best predictor. For GLP-1s specifically, a seven-study meta-analysis of 680 men found total testosterone, free testosterone, SHBG, LH and FSH all rose. Two meta-analyses then disagree on the mechanism — one ties the rise to the weight loss, the other argues it is independent of it — and we are not going to pick a side they cannot settle. What none of this is: a hard-outcome trial, or evidence that it matches replacement for symptom relief. In the one randomised head-to-head, erectile function improved only in the testosterone arm.
Do GLP-1s make you lose muscle?▾
Less specifically than the internet believes. Pooled across 20 randomised trials and 15,782 people using DXA or MRI, lean tissue was 25.4% of the weight lost on tirzepatide, 26.8% on liraglutide and 35.2% on semaglutide. Lifestyle-only weight loss ran 26.2% — statistically indistinguishable from the incretins as a group. So losing weight costs lean tissue whatever causes it. The one intervention in that dataset that changed the number was resistance training, at 17.5%. The molecule difference is real and worth knowing, and the training answer matters more than either drug.
Is there still a boxed warning on testosterone?▾
Not for cardiovascular risk. Xyosted's and Jatenzo's labels both record the boxed warning being removed in March 2025, following the TRAVERSE cardiovascular outcomes trial, which found major adverse cardiac events in 7.0% on testosterone gel against 7.3% on placebo — non-inferior, hazard ratio 0.96. Depo-Testosterone has no boxed warning either. The only testosterone boxed warning still in force that we found is on topical gels, and it is about secondary exposure — virilisation reported in children who touched an unwashed application site. The under-reported half of TRAVERSE is in the same label's adverse-reaction table: bone fracture 3.5% against 2.5%, non-fatal arrhythmias warranting intervention 5.2% against 3.3%, acute kidney injury 2.3% against 1.5%. Different testosterone products currently say different things about cardiovascular risk, so read the label for the product you were actually prescribed.
Do sermorelin or ipamorelin work better in men?▾
There is exactly one sex-split human result and it is thirty years old. A 1997 single-blind trial of nine men and ten women aged 55 to 71 found a GHRH(1-29) analogue increased lean body mass in men only, improved insulin sensitivity in men only, and improved well-being and libido in men only — the authors described anabolic effects favouring men more than women, and called for further work that has not been done. Nineteen people, an analogue rather than sermorelin itself. Ipamorelin's only human study is a pharmacokinetic one in 40 men, so no sex comparison was even possible, and CJC-1295's human data is peak hormone concentrations with no body-composition endpoint at all. The complete search record is on our peptides for men page.
This page is informational and not medical advice, and nothing on it is a recommendation to start or stop testosterone therapy — that is a decision for you and a licensed clinician, and it should be made on bloodwork. Compounded GLP-1 medications are available by prescription only after clinician review and are not FDA-approved; the labelled findings quoted here come from approved branded products and do not transfer automatically to a compounded one. The fertility figures cited come from trials of healthy men on supraphysiologic doses and describe what happened in those trials, not a guarantee for any individual. Every price was verified against each provider's own site in a rendered browser on the date shown on the board it came from, and can change without notice.
