Best weight loss peptides for women, ranked on the choice that actually differs
Two lines of FDA labeling separate these drugs for a woman, and they point in opposite directions. Both attach to a specific molecule — which makes a provider that will not tell you which molecule it is shipping unable to serve you at any price. 2 of the 16 here are in that position.
On the pill? Tirzepatide has an instruction attached.
Zepbound's label, §7.2 and §8.3, advises anyone using oral hormonal contraceptives to switch to a non-oral method, or add a barrier method, for 4 weeks after starting — and for 4 weeks after each dose increase. The cause is delayed gastric emptying; §12.3 measured mean peak ethinyl estradiol falling 59% alongside a single 5 mg dose. Mounjaro says the same. Wegovy and Ozempic say nothing of the kind, and their labels report no meaningful interaction with ethinyl estradiol or levonorgestrel at all. Contraception not taken by mouth is unaffected either way.
Planning a pregnancy? Semaglutide has one instead.
Wegovy's §8.3 is a single sentence: because of the potential for fetal harm, discontinue at least 2 months before a planned pregnancy, to account for semaglutide's long half-life. Ozempic repeats it. Neither tirzepatide label states any pre-conception interval — so that rule must not be carried across to Zepbound. Both drugs say to stop when a pregnancy is recognized, and both say weight loss offers no benefit in pregnancy and may cause fetal harm.
Every quote above was read from the current prescribing information on DailyMed on 2026-07-31. None of it applies to a compounded product, which carries no FDA label at all — every provider here sells compounded drugs, and that is a reason for more caution than the label implies, not less.
/ The ranking
Some of these are affiliate links and we may earn a commission at no extra cost to you (disclosure). Rows marked Partner are the paid ones. Full write-ups below.
“Flat price” means one all-in monthly figure with no separate membership or lab fee; any other pricing chip names the mechanic that gets in the way. “Labs” is whether bloodwork is required, optional, or not used. The pharmacy chip states a facility type (503A pharmacy, 503B facility) only where the provider publishes one we could cite; “Not disclosed” means we read their site and they do not say, and “Unverified” means nobody has checked this company's pharmacy sourcing yet — of the providers we rank, only two publish a facility type at all. Every provider here includes the clinician consult. Prices were verified on each provider's own site in 2026 and can change without notice.
Both molecules, both prices, no lever
$297/mo flat
1
Direct Meds
The only provider here selling both molecules at a rate with no lever attached to it.
$297/month for the injectable; a sublingual format is referenced at $249/month in the site's FAQ
Compounded GLP-1 telehealth that names semaglutide and tirzepatide as two distinct products and prices each on its own, with neither figure resting on a prepay tier, an auto-refill enrollment or an introductory month. For a reader whose choice of molecule is a clinical decision rather than a budget one, that is the whole point: you can price the switch before you make it, and the number does not move when you do. It is the most expensive way to buy either drug here, and it is the only row where both prices mean what they say.
Strengths
Both molecules are separately named products with their own published monthly rate — the choice this page is about is a choice you can actually make here
Neither price depends on a prepay tier, an auto-refill enrollment or a first-month discount, so switching molecules does not reprice your plan
No commitment means a switch mid-treatment is not a forfeited prepayment, which matters if a pregnancy plan or a contraceptive change forces one
Trade-offs
The highest published price here for either molecule
Nothing on the site addresses the labeled tirzepatide contraceptive instruction — you will be the one raising it at intake
No bundled coaching or dietitian support, so the wrapper around the prescription is thin compared with several cheaper rows
Received an FDA warning letter in September 2025 over its marketing of compounded semaglutide and tirzepatide — worth reading before you buy
Visit Direct Meds ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
The rest of the field
15 more providers, ordered from those that let you pick and price the molecule down to those that will not name it. Every price shown is inherited unchanged from the rendered-browser check behind our semaglutide ranking and our tirzepatide ranking — this page re-argues the field, it does not re-price it.
2
Bodybuilding Health+
Both drugs named and priced, at the lowest clean pair of figures here.
BH
$179/month with no prepay required, per the same four-tier ladder printed on both the homepage and the /glp-1 page ($159 / $149 / $139 per month on 3-, 6-, and 12-month terms); a "$100 OFF YOUR FIRST MONTH — LIMITED TIME OFFER" banner now runs above it, and the /glp-1 product card reframes the same figure as "$179 first month" with $279 struck through
The compounded-Rx arm of retailer Bodybuilding.com, whose catalog names semaglutide and tirzepatide separately and prices each. On the lens this page ranks on, it does everything asked: you know which molecule you are buying, and you know what each costs before you choose. The catch is the shape of the bill rather than the drug — both figures sit on prepay plan lengths, so the cheapest way to buy is also the way that penalizes changing your mind, and changing your mind is exactly what a contraceptive change or a pregnancy plan may require.
Strengths
Names both molecules as distinct products and prices them separately — no blended or unspecified GLP-1 SKU
The lowest pair of unqualified figures here for the two molecules side by side
A deep peptide catalog beyond GLP-1s if you want one account for several things
Trade-offs
Both figures are prepay-shaped, so a mid-course switch between molecules is a commercial decision as well as a clinical one
All sales final and the consult fee is non-refundable — an unhelpful combination if intake surfaces a reason to change drug
Nothing on the site discusses the labeled tirzepatide oral-contraceptive instruction
Two named molecules, two flat figures, one tier ladder printed in full.
$249 per month with no prepay required — but a "month" is a 4-week billing cycle ("Billed every 4 weeks" is printed on the 1-month tier), so 13 charges land in a calendar year and the true calendar-month cost is about $271; it drops to $237/$224/$212 per month on 3-/6-/12-month terms, billed as one charge every 12/24/48 weeks respectively, with advertised promo codes SUMMER50 ($50 off 1-month plans) and SUMMER100 ($100 off 3-month-and-longer plans) on top
Compounded GLP-1 telehealth that publishes its plan ladder openly and names both drugs as separate products. The molecule choice is real and priced, which puts it in the top tier here. Read the billing unit before you commit, though: on this company's longevity line every tier is billed on a four-week cycle while quoting a monthly price, which is thirteen charges a year rather than twelve — worth confirming applies or does not apply to the weight-loss plan you are quoted, because a mid-course molecule switch inside a prepaid cycle is where that detail starts costing money.
Strengths
Both molecules named and separately priced, with the full tier ladder and the saving against each printed on one page
A genuine shortest-term option exists rather than a mandatory quarterly prepay
Provider care is described as included in the plan price rather than billed on top
Trade-offs
This company's other product lines bill on a four-week cycle while quoting a monthly rate — confirm the cadence on the weight-loss plan before prepaying
The advertised floor figures require the longest commitment, which is the commitment a molecule switch is worst-suited to
No published discussion of the labeled contraceptive interaction on the tirzepatide side
Visit Enhance MD ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
4
RxSpan MD
A clean semaglutide rate beside a tirzepatide price labeled first-month-only.
$249/month with no prepay; $219/month on a 3-month plan, $199/month on a 6-month plan, $194/month on a 12-month plan
Physician-led telehealth with both molecules on the menu. The semaglutide figure is a flat published monthly rate; the tirzepatide figure carries this brand's site-wide "(For the first month)" label, which runs across its longevity category too. That asymmetry lands awkwardly for this reader specifically: the drug with the labeled contraceptive instruction is also the drug whose ongoing price is the one you cannot read off the page, so the molecule that costs you a barrier-method plan is also the molecule whose real cost is unknown.
Strengths
Both molecules named as separate products with separate figures
Inclusions are stated explicitly — consult, medication, supplies, shipping and support
Available in all 50 states, stated plainly
Trade-offs
The tirzepatide price is labeled first-month-only while a cancel-anytime monthly tier is sold at the same figure; the two statements contradict each other
So the ongoing cost of the molecule carrying the labeled contraceptive instruction is the one number you cannot read
No dose, strength or product-page detail is reachable outside the intake quiz
Visit RxSpan MD ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
Full write-ups for the remaining 12 providers▾
5
Strut Health
The cheapest semaglutide figure here, reachable only by enrolling in auto-refill.
$99/month, explicitly the auto-refill (21% discount) rate — the one-off, non-recurring price is not printed on the page
Compounded telehealth selling both molecules, and one of the few that segments its weight-loss catalog by sex on its own site. The semaglutide headline is the lowest here by a wide margin, and it is an auto-refill price — the low number and the recurring shipment are the same decision. Auto-refill is the commitment shape that fits a molecule switch worst: a barrier-method plan or a pregnancy decision that changes the drug mid-course runs into a shipment already scheduled. Also worth knowing before you weigh the price: this company received an FDA warning letter in February 2026 over marketing claims.
Strengths
Both molecules named and separately priced, with a stated non-auto-refill rate on the tirzepatide side so the size of the discount is visible
The lowest semaglutide figure here
Segments its weight-loss catalog rather than selling one undifferentiated program
Trade-offs
The headline semaglutide rate requires enrolling in auto-refill — the commitment shape least compatible with changing molecule mid-course
Received an FDA warning letter in February 2026 over marketing claims
Nothing on the site addresses the labeled tirzepatide contraceptive instruction
Visit Strut Health ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
6
MadeMed
Both molecules, real clinical caution — and no month-to-month plan at any price.
The homepage/product hero reads "From $199/mo," but the page's own plan selector defaults to a Quarterly plan at $239/month, and the cheapest tier reachable is $199/month on a 6-month prepay ($1,194 billed at once)
Compounded telehealth that names both drugs and runs more pre-prescribing clinical process than most of this field. The structural problem for this reader is the term: the shortest commitment available on any product line here is a quarterly prepay, so the labeled four-week barrier-method window that opens at initiation and again at every tirzepatide dose escalation sits inside a block of treatment you have already paid for. If that window is a reason to change molecule, you change it having pre-purchased the other one.
Strengths
Both molecules named as separate products with published figures
More pre-prescribing clinical process than most providers here, including required bloodwork on some lines
Consultation, supplies and shipping are stated as included rather than billed on top
Trade-offs
No true month-to-month option exists at any price — the shortest term is a quarterly prepay
So a molecule switch prompted by a contraceptive or pregnancy decision is made against a prepaid quarter
Required lab work on some lines is not priced anywhere, so the real cost of starting is unknowable from the page
Visit MadeMed ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
7
Sprout Health
Both molecules named, and the semaglutide figure is a three-month supply divided by three.
"Starting at $615" for a three-month supply, marked down to "now from $465" for the same three-month supply — about $155/month at the markdown price
Compounded GLP-1 weight-loss telehealth. Both drugs are named, which clears the bar this site is about, but the semaglutide figure is derived from a multi-month supply rather than quoted as a monthly rate, and the tirzepatide figure's mechanism is not published. Worth weighing beside the pricing: this company received an FDA warning letter in September 2025 over marketing its compounded GLP-1 medications as "FDA-approved" — which is the same category of claim a reader has to see through to understand that none of the labeled instructions on this page come with the compounded version.
Strengths
Both molecules named as distinct products
Unusually direct elsewhere on the site about compounded products not being FDA-approved or FDA-evaluated
States plainly that it is not the pharmacy and not the manufacturer
Trade-offs
The semaglutide figure describes a three-month supply, not a monthly rate you can plan a molecule switch against
The tirzepatide figure's pricing mechanism is not published at all
Received an FDA warning letter in September 2025 over marketing compounded GLP-1s as FDA-approved
Visit Sprout Health ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
8
yourEra
A flat tirzepatide rate beside a semaglutide floor we could not confirm.
"Semaglutide GLP-1 — from $79/mo" is the only figure published, on the homepage; every product card and eligibility CTA routes to the intake quiz rather than to any dedicated pricing or plan-tier page
Compounded GLP-1 telehealth with a stated same-price-at-every-dose policy, which is genuinely useful on tirzepatide specifically: the labeled barrier-method window reopens at every dose escalation, and a provider whose price does not move with the dose at least removes one reason to hesitate over titrating. Against that, the semaglutide floor advertised on the site could not be confirmed against a product page, so the cheaper of the two molecules here is the one whose price is least certain.
Strengths
A stated flat price at every dose, so titrating tirzepatide upward does not reprice the plan
Both molecules named, with the tirzepatide figure a specific rate rather than a band
Telehealth visit, prescription and shipping all described as included
Trade-offs
The advertised semaglutide floor could not be confirmed on a product page
This site was found publishing a product whose own purchase links returned 404 on another line, so a reachable advertised price is not a given here
Thin independent footprint; coverage and outcome claims are self-reported
Visit yourEra ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
9
Try Ageless
Both molecules named, and every price on the site disclaimed by the same footnote.
Semaglutide Injection: homepage grid shows list $169 struck through to sale $119; the dedicated product page shows list $229 struck through to the SAME $119 sale price. A stacking promo code ("GLP150") is also advertised for a further $50 off.
Compounded longevity and weight-loss telehealth carrying both molecules alongside sermorelin, NAD+ and a testosterone line. Both drugs are named, which is what this site asks first. What follows is the brand's standing footnote, printed under every price on every product page: exact pricing depends on the dose prescribed, with the final amount shown after clinical review. On a tirzepatide plan that is a compounding problem rather than a rhetorical one, because the labeled barrier-method window reopens at each dose escalation — so the event that changes your contraception plan is also the event that may change your bill.
Strengths
Both molecules named as separate products
One account also covers sermorelin, NAD+ and testosterone if you want a single provider
Discount codes are disclosed by name on the page rather than sprung at checkout
Trade-offs
Every price is disclaimed by a footnote making the final amount dose-dependent, so neither figure is a rate
A dose escalation is therefore both a contraception event and a possible repricing event, and only one of those is disclosed
The semaglutide list price is disputed against other figures on the same site; no published state-availability list
Visit Try Ageless ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
10
Synergy Rx
Two named molecules behind two "starting at" figures and no terms at all.
"Starting at $199" for Compounded Semaglutide (injectable), or "Starting at $299" for an oral dissolving tablet — no dose basis, billing term, or commitment is stated on the product card; a site-wide "Your $100 welcome credit — applied at checkout. No code needed." banner now runs on the homepage, with no stated relationship to the card figures
Compounded GLP-1 and longevity telehealth whose storefront names both drugs as real, priced products — which clears this site's first bar — and then publishes nothing behind either card. Clicking through routes into the intake quiz rather than a product page, so dose basis, billing cadence, consult inclusion and what happens to your price when a dose changes are all unavailable until after you have handed over personal information. A site-wide banner announces a promotion already applied without naming its size, so neither figure can be checked against a base price.
Strengths
Both molecules named as real, separately priced products, confirmed in a rendered browser
Menu is internally consistent across its weight-loss and longevity lines
Free shipping stated site-wide
Trade-offs
Neither figure carries terms — no dose basis, no billing cadence, no confirmation either is a no-lever monthly rate
The route from the price to the product is the intake quiz, so nothing can be checked before you register
A promo banner with no stated size means the displayed prices cannot be checked against anything
Visit Synergy Rx ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
11
HealthRX
Both molecules, both priced twice, and the two figures do not agree with each other.
The dedicated /semaglutide page states "FROM $99/mo" tied to an annual plan; a homepage pricing card states "$99/mo on the 12-month plan" (implying a higher rate on shorter plans, unstated); a separate homepage comparison table states "HealthRX Compounded... from $133/mo." No single figure is repeated consistently across all three.
LegitScript-certified compounded telehealth carrying both drugs. Its NAD+ and testosterone lines publish exemplary dual price ladders — a subscribe column and a one-time column side by side — and its GLP-1 lines do not: on both molecules the site quotes different figures in different places for the same product. For a reader whose molecule choice has a labeled consequence, the specific harm is that you cannot compare the two drugs on this site, because neither drug has one price to compare.
Strengths
Both molecules named as separate products with real product pages
The same brand's non-GLP-1 lines publish a genuine no-subscription price, so the capability plainly exists here
Medication, supplies, provider visit, unlimited follow-ups and shipping stated as included
Trade-offs
Both molecules carry internally inconsistent pricing — the same product is quoted at different figures on different pages
So the two drugs cannot be compared to each other on this site, which is the comparison this page exists to help you make
Visit HealthRX ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
12
Oak Longevity
Both molecules named — and two unreconciled program prices after an August rebuild.
The homepage FAQ reads "Oak's programs start at as little as $119/month, with no hidden membership fees, no surprise charges, and free shipping"; the dedicated /weight-loss page prints "$190/mo" in its comparison table and "start at as little as $190/month or lower!" in its own FAQ — two figures, $71 apart, with no stated relationship between the two. The July check's hero price, $167 comparison-table figure, and "$200 off" new-patient banner are all gone.
Compounded GLP-1 telehealth naming both drugs. An August 2026 homepage rebuild removed the old hero figures, one-price banner and comparison table; what survives is a two-figure contradiction — $119/month on the homepage FAQ against $190/month on the weight-loss page, for the same programs, with no drug or term attached to either. Both molecules are at least identified, so a reader can specify which one they want — but what specifying it costs is not a number this site states once.
Strengths
Both molecules named, so the drug you receive is at least specifiable
Free shipping and no-membership-fee language on the site's own pages
The two remaining figures are on the public site rather than gated behind the quiz
Trade-offs
Two unreconciled program prices ($119 and $190) one click apart, with no drug or term attached to either
The mechanics behind both figures are quiz-gated, so neither advertised price can be checked
Nothing on the site addresses the labeled tirzepatide contraceptive instruction
Visit Oak Longevity ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
13
SHED
Its purchasable product is a generic GLP-1 SKU whose own copy does not say which drug ships.
A site-wide banner advertises "Compounded Semaglutide as low as $159/mo"; the actual purchasable product, "GLP-1 Injections," is priced "Starting at $199/month" and its own description states the specific drug dispensed ("best option will be determined... Semaglutide" is one listed possibility, not a guarantee)
This row sits here for one reason, and it is the reason this page exists. The item a shopper can actually add to cart is not a semaglutide product; it is a "GLP-1 Injections" SKU whose own description says the best option will be determined, with semaglutide listed as one possibility rather than a guarantee. The same weight-loss menu also carries orforglipron, a different molecule again. Everywhere else that ambiguity is a shopping annoyance. Here it is the thing you cannot afford: the four-week barrier-method instruction in the tirzepatide labeling attaches to a specific molecule, and a product that does not tell you which molecule you are on cannot tell you whether that instruction applies to you.
Strengths
A genuine brand-name Wegovy and Zepbound path is offered for readers who want the FDA-approved product and its actual label
Health coaching is bundled into the membership rather than sold on top
Delivery formats and administration frequencies are stated clearly elsewhere on the site
Trade-offs
The purchasable product is a generic GLP-1 SKU; the site's own copy does not guarantee which molecule is dispensed
So the one labeled instruction that separates these two drugs for a woman cannot be applied to what you are taking
A site-wide banner advertises a price the product page does not match, and the dispensing pharmacy is not publicly named
Visit SHED ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
14
Gala Health
The ranking's only menopause-HRT provider, and its GLP-1 is a blended SKU with no molecule named.
The hero advertises "Start now — $179/mo" beside "Cancel anytime"; the same page's cost section answers that compounded GLP-1/GIP "(incl. Tirzepatide) costs $199 per month (all-included, with medical evaluation and ongoing support)" and then repeats "Start for $179/mo" — two figures, no term language anywhere, and nothing stating what makes $179 available or for how long
A split verdict, and both halves matter on this page. On the lens this site ranks on, Gala is near the bottom: it sells no compounded semaglutide at all, its GLP-1 figures describe a blended GLP-1/GIP product rather than a tirzepatide-dedicated one, and no month-to-month rate is published — so the molecule is neither choosable nor named. On everything else this page discusses, it is the only provider on this site that treats the thing driving the weight change rather than only the weight: it is a women's hormone-therapy practice, estradiol and progesterone, which is the perimenopausal half of the question no GLP-1 seller here touches.
Strengths
The only provider on this site running women's hormone therapy — estradiol and progesterone — rather than weight loss alone
Consult and ongoing support described as bundled into the price
Its $179/mo hero figure is among the lowest advertised GLP-1 numbers anywhere here — though what term produces it is no longer stated
Trade-offs
No compounded semaglutide at all, so the molecule with no labeled contraceptive instruction is not available here
The published GLP-1 figures describe a blended GLP-1/GIP SKU, not a tirzepatide-dedicated one — confirm exactly what is being prescribed
Two contradictory figures ($179/mo and $199/mo) with no term or billing language anywhere — the prepay footnote was removed in August 2026
Visit Gala Health ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
15
Breeze Meds
Both molecules named in the navigation, and no price published for either one.
"Starting at $199 — Weight Loss Injections" on the homepage is the first figure this company has published in this site's record of it; no billing unit, cycle, or specific drug is attached to it, and the only path past it is still the intake quiz
Compounded GLP-1 and longevity telehealth. Both drugs appear as named products in the site's own navigation, so the molecule is at least specifiable in principle — but no figure is published for either, and every route to a price runs through the intake quiz. Its longevity line does now publish prices, which the weight-loss line does not, so this is a deliberate gate rather than an unfinished site.
Strengths
Both molecules named as real products in the site's own catalog
Now publishes prices on its longevity line, which it did not previously — the capability exists
Named injection frequencies elsewhere on the site are more detail than several priced competitors give
Trade-offs
No price is published for either molecule; every route to one is the intake quiz
Nothing about terms, cadence or what a dose escalation costs can be read before registering
The site's own navigation redirects off-domain to sibling white-label telehealth sites — a real navigation defect
Visit Breeze Meds ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
16
Care Bare Rx
Both molecules named, one category-wide floor, and no price attached to either drug.
Pricing not published — a $199/mo figure exists only as a category-wide "Weight Loss" floor across all weight-loss drugs, not tied to semaglutide specifically
White-label telehealth naming both molecules with no figure specific to either. The only published number is a category-wide weight-loss floor, which cannot tell you what the choice between the two drugs costs — and on this page that choice is the entire question. A reader here cannot compare the molecules, cannot price a switch, and cannot find out what either costs without registering.
Strengths
Both molecules named rather than sold as an unnamed weight-loss program
Broad catalog if you want one provider for several things
The category floor is at least stated publicly rather than hidden entirely
Trade-offs
No price specific to either molecule is published anywhere
A category-wide floor cannot price the choice between two drugs, which is what this page is about
Whether the consult is included or billed separately is never stated in plain language
Visit Care Bare Rx ↗PartnerShown for honest comparison · verified on the provider's own site in 2026
Straight talk: how we earn — some, not all, of these are affiliate links; start a program through one and we may earn a commission at no extra cost to you. Straight about the rest, too: the write-ups say what each provider is actually worth, and a commission does not change a word of them. Full disclosure here.
How we rank
We do not run sponsored reviews, and nobody pays us to change what we write about a provider. Affiliate partners are listed ahead of non-partners, and the ordering within that group runs on the four factors below — deliberately different from every sibling ranking, because the dominant question here is not price. It is which drug you are on.
Can you choose the molecule, and are you told which one
The two labeled facts on this page attach to a specific drug, not to “GLP-1s” as a category. So the first thing this site sorts on is whether a provider sells both as separately named products with separate published prices — 12 of 16 do — or sells something more vague. 2 providers here either will not name the molecule that ships or sell it blended, and 2 publish no price for either drug at all.
What the commitment does to a change of mind
Second: what happens if the answer changes. A contraceptive change, a pregnancy plan or a dose escalation can all be reasons to switch molecule mid-treatment, and on a prepaid quarter or an enrolled auto-refill that switch costs money as well as a conversation. Rows whose price depends on a lever are ranked below rows whose price does not.
Whether anyone treats the driver, not just the weight
Third, and it separates exactly one provider: through the menopause transition fat gain roughly doubles and lean mass falls, while the rate of weight gain does not change at all. A scale will miss that entirely, and so will a tape measure — waist circumference grew at statistically indistinguishable rates before, during and after the transition in the same cohort. One provider here runs a women's hormone practice alongside its GLP-1. It is named in the table below.
What we refused to rank on
Not efficacy by sex, because no label reports one. WEGOVY and ZEPBOUND both say only that weight reduction was seen irrespective of sex, and all four labels we read say sex has no clinically relevant effect on how the drug is handled. The published literature does show women losing slightly more — around 1 kg — which is a real signal and not a different recommendation. See our full evidence page for women for the searches behind that.
PCOS is a real indication here, and a narrower one than it is sold as
This is the one place where the trials were run in women by design, so it is worth being exact about what they found. Randomized trials in women with PCOS show weight and waist reduction, a lower free androgen index, higher SHBG, substantially less liver and visceral fat, and modestly more regular bleeding — a 26-week randomized trial put the improvement in bleeding ratio at 0.14 (95% CI 0.03 to 0.24) over placebo. Two meta-analyses disagree on whether insulin resistance improves at all.
What they do not show is a baby. No trial has reported live birth. The 2023 international evidence-based guideline conditionally supports these drugs for weight in PCOS, and separately recommends using anti-obesity agents in PCOS for reproductive outcomes only in research settings. The same guideline adds a practice point that belongs on this page more than anywhere else: ensure effective contraception where pregnancy is possible, because pregnancy safety data are lacking. Combine that with the tirzepatide instruction above and the two reinforce each other.
If this started in your forties, the scale is the wrong instrument
In the Study of Women's Health Across the Nation, the rate of fat gain roughly doubled at the start of the menopause transition and lean mass declined, both continuing until about two years after the final period — while the rate of weight gain did not accelerate at all. It is a recomposition, not extra pounds. Regional measurement in the same cohort found android fat accelerating from 1.21% to 5.54% a year and visceral fat beginning to climb at 6.24% a year, with waist circumference growing at statistically indistinguishable rates throughout — so a tape measure misses it too. A related analysis links that lean-mass loss to later bone density and fracture, which is the clinical end of a change usually discussed as cosmetic.
★ What our ranking cannot do about it. Exactly one provider on this ranking runs a women's hormone practice — Gala Health, estradiol and progesterone — and it is ranked near the bottom here because it sells no compounded semaglutide and prices a blended GLP-1/GIP product rather than a named molecule. There is no provider on this site that does both halves well. We would rather say that than rank someone first for a capability nobody has.
The one sex split the labels actually publish is an adverse reaction
We went looking for sex-split efficacy rows and there are none. What there is, in Wegovy's §6.1, is hair loss: reported in 4% of women against 0.9% of men on the 2.4 mg dose, and 8.4% of women against 0.2% of men on 7.2 mg. Zepbound's §6.1 reports 7.1% of women against 0.5% of men. Both labels attribute it to the weight reduction rather than to the drug, which fits the leading proposed mechanism — telogen effluvium after rapid loss — and means it is generally reversible. A meta-analysis of nine interventional studies in 4,114 users puts the pooled risk ratio against placebo at roughly 3.3, while noting causality is not established.
One more, and it is the reason the sentence above is not the whole story: in the cardiovascular outcomes trial, hip and pelvis fractures were reported in 1% of women on Wegovy against 0.2% on placebo, and in 2.4% against 0.6% of patients aged 75 and over. There is no equivalent statement in the tirzepatide label. Neither of these is a reason not to treat obesity. Both are things a woman is entitled to have been told.
This ranking ranks on molecule control. Our semaglutide ranking asks whether a site agrees with itself, our tirzepatide ranking asks what month two really costs, and our cheapest-tirzepatide page asks how low the number goes with every lever pulled. The men's version of the providers here reaches the opposite conclusion about which molecule to prefer, from a different evidence base — which is the clearest proof we can offer that these two pages were researched rather than duplicated.
Questions we get asked
Do GLP-1 weight loss drugs affect birth control?▾
Tirzepatide does, and semaglutide does not. Zepbound's labeling (sections 7.2 and 8.3) advises patients using oral hormonal contraceptives to switch to a non-oral method, or add a barrier method, for 4 weeks after starting and for 4 weeks after each dose increase — because tirzepatide delays gastric emptying, most strongly after the first dose of each step. Mounjaro carries the same instruction. Wegovy and Ozempic carry no equivalent advice, and that absence is backed by data rather than silence: Wegovy's own section 12.3 lists ethinyl estradiol and levonorgestrel among drugs with no clinically significant pharmacokinetic difference alongside semaglutide. Contraception that is not taken by mouth is not affected either way.
How long before trying to conceive should I stop a GLP-1?▾
For semaglutide the label gives a number. Wegovy section 8.3, in full, reads: discontinue at least 2 months before a planned pregnancy, to account for the long half-life of semaglutide. Ozempic says the same. The tirzepatide labels state no pre-conception interval at all — searches for "planned pregnancy" and "washout" return nothing in either Zepbound or Mounjaro — so the semaglutide rule must not be transferred onto it. Both labels do say to stop when a pregnancy is recognized, and both say weight loss offers no benefit during pregnancy and may cause fetal harm. This is a conversation to have with your prescriber, not a schedule to set from a web page.
Do women lose more weight than men on GLP-1s?▾
A little, and much less than the internet suggests. No FDA label reports a sex split in efficacy at all — Wegovy and Zepbound both state only that weight reduction was seen irrespective of sex. In the published literature the direction is consistent but the size is modest: a meta-analysis of 14 studies found women lost about 1 kg and 1.7 percentage points more, with no difference at all for exenatide. A 2026 JAMA Internal Medicine review found only about a fifth of trials analyzed by sex in the first place, and no sex-subgroup analysis has been published for tirzepatide specifically. It is a real signal. It is not a reason to expect a different result.
Can you take peptides while pregnant or breastfeeding?▾
Not for weight loss. Both labels say plainly that weight loss offers no benefit to a pregnant patient and may cause fetal harm, and both instruct discontinuation when a pregnancy is recognized. Breastfeeding is now split by formulation: Wegovy tablets carry an affirmative instruction that breastfeeding is not recommended during treatment, because of a possible accumulation of the absorption enhancer SNAC in an infant, while Wegovy injection — which does not contain it — gets only the standard benefit-and-risk balancing language. For the compounded products every provider here actually sells, there is no label at all, which is a reason for more caution, not less.
Do peptides like BPC-157 or sermorelin work for women?▾
Nobody knows, because it has not been studied. There is no randomized controlled trial of BPC-157 in the indexed literature in either sex, and the only all-female human report is an uncontrolled, unblinded twelve-person pilot. No randomized trial is indexed under the name sermorelin. The full search record, with every query and the number of records it returned, is on our peptides for women page — a null finding is worth nothing if you cannot repeat it.
This page is informational and not medical advice, and nothing on it is a recommendation to take or avoid any medication during pregnancy, while breastfeeding, or while trying to conceive — those are decisions for you and a licensed clinician. Compounded GLP-1 medications are available by prescription only after clinician review and are not FDA-approved; the labeled findings quoted here come from the approved branded products and do not transfer automatically to a compounded one. Every price was verified against each provider's own site in a rendered browser on the date shown here it came from, and can change without notice. Where a provider publishes no price we say so rather than estimate.
