Provider review
Signos review
Early cancellation on the 3- or 6-month plan can carry a fee, no proration
Signos bundles clinician-prescribed compounded GLP-1 medication with an FDA-cleared Stelo biosensor by Dexcom (a name confirmed live, not in prior research) and a coaching app, at $199/month on a 3- or 6-month plan, confirmed live — prior research had recorded only a 6-month term. Its own FAQ states early cancellations on either term "may be subject to a cancellation fee" with no prorated refunds, confirmed live. Neither semaglutide nor tirzepatide is named explicitly before signup; the site uses generic "GLP-1 medication" language throughout, with the specific drug determined by the provider after intake. Clinical services run through OpenLoop Health and other independent clinician networks, confirmed live, though the dispensing pharmacy itself is still described only as "certified U.S. pharmacies."
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On this page
The verdict
Signos' core differentiator is real and genuinely useful — a named, FDA-cleared CGM (Stelo by Dexcom) bundled with the medication, giving you glucose feedback most GLP-1 telehealth programs don't offer. But the $199/mo price assumes you complete the full 3- or 6-month term; canceling early can trigger a fee with no prorated refund, confirmed live, and you won't know in advance which GLP-1 drug you'll actually be prescribed since the site never names one before you sign up.
Signos is not ranked on any of our boards. This is a standalone read of what the company publishes about itself — the providers we do rank in this category are on our semaglutide provider ranking. Nothing on this page is a performance claim — see the evidence review for what these compounds do and do not do.
Who it is for, and who it is not
A good fit if
- You want a continuous glucose monitor bundled with your GLP-1 program, not sold separately
- You're comfortable committing to the full 3- or 6-month term to avoid a cancellation fee
- You want app-based coaching and real-time glucose data alongside medication
Look elsewhere if
- You want to know upfront whether you'll get semaglutide or tirzepatide — the site doesn't specify before signup
- You want to cancel mid-term without risking a fee or losing a prorated refund
- You want a named compounding pharmacy rather than general "certified U.S. pharmacies" language
What it actually costs
What they advertise
Signos+ plan: $199/month, confirmed live on signos.com/plans.
What you actually pay, month to month
$199/month applies across the 3- or 6-month term; early cancellation may carry a fee with no proration, confirmed live.
The commitment trap
The $199/mo price assumes completing the full term; canceling early can trigger a fee, and refunds aren't prorated.
Checked live on Signos's own site at https://www.signos.com/plans?plan=glp in August 2026. Prices change without notice — confirm before you buy. Work out what a vial actually gives you with our peptide dose calculator.
What is included
The cheapest headline number in this category is often the one with the least attached to it. Here is what Signos bundles in, and what it does not.
Clinician consult
Provider prescription through OpenLoop Health or an independent…
clinician network, confirmed live.
Bloodwork / labs
Not addressed in the sources read.
Follow-ups and dose changes
Not addressed with a specific cadence in the sources read.
Human support
Dietitian access and app coaching, confirmed live.
Injection supplies
Stelo biosensor CGM by Dexcom included at no extra cost,…
confirmed live.
Shipping
Free rapid shipping, confirmed live.
Pharmacy, labs and oversight
The pharmacy
Described only as "certified U.S. pharmacies"; no specific name disclosed, confirmed live.
Oversight
Provider prescription through OpenLoop Health or an independent clinician network, confirmed live. Not addressed with a specific cadence in the sources read.
Compounded peptides are not FDA-approved products, and a 503A pharmacy compounds for a named patient while a 503B outsourcing facility manufactures in batches under CGMP. Neither is a quality guarantee on its own — a named facility is simply a fact you can check, and an unnamed “partner pharmacy network” is not. Our guide to verifying a certificate of analysis covers what to ask for.
Where you can get it
Not published anywhere in the sources read, confirmed live.
The honest cons
The part they would rather you skipped
Signos' own FAQ states early cancellations on the 3- or 6-month plan "may be subject to a cancellation fee" with no prorated refund, confirmed live — worth knowing before you sign up, since the $199/mo headline price assumes you finish the full term.
- Early cancellation may carry a fee with no prorated refund
- Neither semaglutide nor tirzepatide is named before signup — the drug is provider-determined post-intake
- Compounding pharmacy never individually named
- State coverage not published anywhere on the site
None of this is unique to Signos — the whole category shares it. What we hold against a provider is the part it hides, and the ways vendors hide things are catalogued in our vendor red-flags guide.
How it compares
The providers we rank on our semaglutide provider ranking, in the order that board ranks them. Signos is not among them: it is reviewed here, not ranked there, and we would rather show you the comparison than pretend the two are the same thing.
- BHBodybuilding Health+One of the deepest peptide catalogues here, and the loosest one
- Enhance MDWrites a flat-price-at-every-dose policy down — and charges near the top for it
- RxSpan MDOral tablet only, at a real $179 monthly rate
- Direct MedsThe plainest price mechanics on either board, from a company with an FDA warning letter
- Synergy RxPublishes a starting number, and nothing about what it commits you to
- Sprout HealthA $150 markdown the site never explains, and a semaglutide price quoted by the quarter
- Strut HealthInjection or troche, but $119 is the auto-refill price only
- MadeMedPrices are published — but there is no monthly option at all
7 more providers rank on our semaglutide provider ranking — see the full ranking. Every provider we review →
Read this before you buy
A provider comparison is half the decision. The other half is whether the compound does anything for you at all — and whether it is allowed where you compete. Growth-hormone secretagogues are banned in tested sport, year-round, and a prescription does not change that.
Facts on this page reflect Signos's own public disclosures when we last checked them, in August 2026. Prices and terms change without notice — confirm on Signos's site before you buy. Provider names and logos on this page identify the company under review; their use does not imply endorsement, sponsorship or affiliation. This page is informational and not medical advice; compounded peptides are not FDA-approved, and growth-hormone secretagogues are banned in tested sport year-round. See our disclosure and editorial policy.